Luke and Bo were raised by their Uncle Jesse Duke and his wife, Martha [now deceased] after their parents were killed. In his younger days, Jesse used to run moonshine for the Ridge Runners Association along with J. D. Hogg (who has since become Jesse's sworn enemy). Back then, Jesse drove a super fast car called "Black Tilly" (also called "Sweet Tilly"), but today, he drives a rusty 1970s Ford F-Series pick-up truck.

Swamp Molly, an old moon shining colleague of Uncle Jesse's saved him from the Feds back in 1938 and still occasionally tempts Jesse to make "one last run." But Jesse's new responsibilities to his nephews and niece makes him think twice about taking such a risky venture, especially since Luke and Bo were caught by the government for running moonshine.

Luckily for the boys, Jesse made a deal with the Feds to stop running moonshine. In exchange, the Duke boys wouldn't have to serve any jail time, but they were restricted from crossing county lines, and from carrying fire arms until their probation period expired. Hence, the boy's affinity for the bow and arrow.

Besides worrying about the terms of their probation, the Dukes' Boys main day-to-day threat was Boss Hogg, a fat little southern politician dressed in white who loved to eat and, even more, loved to frame the Duke Boys for crimes they didn't commit.

Here's a short list of the many times Boss Hogg tried to get the goods on the Duke Boys.

• Boss hires two crooks disguised as Bo and Luke  to rob an armored truck with a duplicate General Lee. 
• Boss frames Bo and Luke for passing a bad check. Jesse signs away the Duke farm to go his bail.
• Boss hires a crooked magician to frame Bo and Luke for stealing the orphanage money and then asks Jesse for his moonshine recipe for the release of Bo and Luke.
• Boss frames Miz Tisdale for mail fraud and the Dukes hide her out at the farm.
• Boss frames the Dukes for possession of illegal gambling devices.
• Boss frames the Dukes for stealing a bag full of stolen credit cards left by thieves.
• Boss hires some crooks to rob the TV stores and frames Bo and Luke for it.
• Boss Hogg schemes to steal $1 million in old, raggedy bills marked to be burned at the Federal Reserve and plans on framing the Duke boys for the armored truck robbery so his bank can collect on the insurance money.
• Boss Hogg frames Bo and Luke for possession of illegal moonshine
• Boss has Coy, Vance and Daisy framed and sends them to Chickasaw County where they are arrested by Sheriff Little
• Bo and Luke are framed for gold robbery so Boss can to collect the insurance.
• Bo and Luke are suspected of running a smuggling ring when they deliver cars to Augie Detwiler - the owner of the derby in town
• Boss Hogg frames Bo and Luke for a series of tractor thefts committed by another group of thieves hired by the Boss. 

As for the Duke Boys, Luke Duke is the oldest of the cousins. He is an ex-Marine, musically inclined and the more responsible of the Duke cousins. Luke always slid across the hood of the General Lee, to quickly gain access to the passenger side of the car. Bo Duke, the younger womanizing cousin, did most of the driving, but when Luke got behind the wheel, it can best be summarized in the trademark catchphrase of Bo Duke... "Yeeeee--Haaa!"  However, Bo Duke was the one most likely to punch someone, jump the General Lee over a creek, river or ravine or run the bad guys off the road. Bo's CB handle is Lost Sheep #2;  Luke's is Lost Sheep #1.

In late 1982 and early 1983 Luke spent time on the NASCAR circuit with cousin Bo. Surprisingly, in 1983 the Duke’s discovered that Luke’s baby brother Judd [thought dead] was well and alive. In later years, Luke become a firefighter for the forestry service while Bo Duke eventually returned to the Nascar circuit.

When Luke and Bo left to race NASCAR uncle Jesse supervised the antics of Coy and Vance, two other look alike cousins who continued the battle against Boss Hogg. With the return of Luke and Bo, Coy and Vance left leave Hazzard to take care of a sick relative. After successfully stopping a land developer build a theme park on his farm, Jesse quietly passed away on Christmas Day, 1997.

As for the beautiful cousin, Daisy Duke, she was a waitress at the "Boss Hogg's Boar’s Nest bar and restaurant. She dressed in tight fitting shorts as she served her rowdy customers. Daisy worked at the Boar's Nest as collateral for a loan taken out by Uncle Jesse. Once voted Miss Tri-Counties, the beautiful Daisy married L.D. but when he ran off, she returned to college to get her doctorate in biology at Duke University in North Carolina. It was once said about Daisy "She drives like Richard  Petty, shoots like Annie Oakley, and knows all of the words to all of Dolly Parton's songs." Yeeeee--Haaa! Now ain't she somethin' special?"

The real love of her life was Deputy Enos ("Possum on a gum bush!") Strate whom Daisy will probably end up marrying [she left him at the altar twice]. The first time Enos ("the oldest virgin in Hazzard County") got hives just before the wedding; the second time, Daisy ex-husband (L.D.) came back into her life and reminded her just how married life was and so she decided to stop the wedding.

One of the benefits of working at the Boar's Nest was getting to see all the talented country western singers who performed over time. They included the likes of  country star Candy Dix (Luke's old girlfriend from the Marines); Donna Fargo; Johnny Paycheck; Mickey Gilley (he performed a charity concert at Hazzard Square); Tammy Wynette (she sings "Rocky Top"); Hoyt Axton (he sings "Out-of-State-Cars"); Dottie West; Freddie Fender; and The Oak Ridge Boys (they sing "Old Time Lovin'")

Once when Loretta Lynn detoured through Hazzard County, she stopped at the Boar's Nest and got kidnapped by a trio mini-band who demanded $1136.15 ransom. Luckily, the Duke boys were on hand to rescue her and later hear her perform.

Boss Hogg, Bo, Daisy, Luke and Rosco P. Coltrane

Other people to cross the Duke's path included Vance's old girlfriend, Jenny; elderly, motorcycle-riding postmistress, Miz Emma Tizdale; Boss Hogg's cousin, Cletus Hogg; Rosco's basset hound called Flash (who always barks at Boss Hogg but likes the Dukes);  Boss' devious  college-educated nephew Hughie Hogg (who dresses in white and rides around in a white convertible Volkswagen Beetle); Boss' devious nephew Dewey who is Hughie's brother; Boss' rich, polite counterfeiter nephew Jamie Lee Hogg; Boss Hogg's honest, rich twin brother Abe; the stern, towering Sheriff Edward Thomas "Big Ed" Little of Chickasaw County; Natasha, a Russian gymnast team who defects and hides out at the Duke farm; and of course Cooter Davenport, the town mechanic who serviced "The General Lee."

The Duke's other relatives included Gaylord Duke, a cousin from London, England; Judd Kaine, Luke's boxer brother, who turns up in Hazzard County after many thought him dead; the Duke's great-grandparents Hank and Joe; Cousin Dixie; and Jeb Stuart Duke, the Duke's motorcycle riding visiting cousin.

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